High Performance Computing Instrumentation and Research Productivity in U.S. Universities

This paper studies the relationship between investments in High-Performance Computing (HPC) instrumentation and research competitiveness. Measures of institutional HPC investment are computed from data that is readily available from the Top 500 list, a list that has been published twice a year since 1993 that lists the fastest 500 computers in the world at that time. Institutions that are studied include US doctoral-granting institutions that fall into the very high or high research rankings according to the Carnegie Foundation classifications and additional institutions that have had entries in the Top 500 list. Research competitiveness is derived from federal funding data, compilations of scholarly publications, and institutional rankings. Correlation and Two Stage Least Square regression is used to analyze the research-related returns to investment in HPC. Two models are examined and give results that are both economically and statistically significant. Appearance on the Top 500 list is associated with a contemporaneous increase in NSF funding levels as well as a contemporaneous increase in the number of publications. The rate of depreciation in returns to HPC is rapid. The conclusion is that consistent investments in HPC at even modest levels are strongly correlated to research competitiveness

SARS-CoV-2 seroprevalence among the general population and healthcare workers in India, December 2020–January 2021

Background: Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May–June 2020 and 7.1% in August–September 2020. A third serosurvey was conducted between December 2020 and January 2021 to estimate the seroprevalence of SARS-CoV-2 infection among the general population and healthcare workers (HCWs) in India. Methods: The third serosurvey was conducted in the same 70 districts as the first and second serosurveys. For each district, at least 400 individuals aged ≥10 years from the general population and 100 HCWs from subdistrict-level health facilities were enrolled. Serum samples from the general population were tested for the presence of immunoglobulin G (IgG) antibodies against the nucleocapsid (N) and spike (S1-RBD) proteins of SARS-CoV-2, whereas serum samples from HCWs were tested for anti-S1-RBD. Weighted seroprevalence adjusted for assay characteristics was estimated. Results: Of the 28,598 serum samples from the general population, 4585 (16%) had IgG antibodies against the N protein, 6647 (23.2%) had IgG antibodies against the S1-RBD protein, and 7436 (26%) had IgG antibodies against either the N protein or the S1-RBD protein. Weighted and assay-characteristic-adjusted seroprevalence against either of the antibodies was 24.1% [95% confidence interval (CI) 23.0–25.3%]. Among 7385 HCWs, the seroprevalence of anti-S1-RBD IgG antibodies was 25.6% (95% CI 23.5–27.8%). Conclusions: Nearly one in four individuals aged ≥10 years from the general population as well as HCWs in India had been exposed to SARS-CoV-2 by December 2020